Publications

For full list of publications, see PubMed and Google Scholar
 

PTOA: Prevention, Drug Effects, and Repair

  • Black RM, Wang Y, Struglics A, Lorenzo P, Chubinskaya S, Grodzinsky AJ, Önnerfjord P. "Proteomic clustering reveals the kinetics of disease biomarkers in bovine and human models of post-traumatic osteoarthritis." Osteoarthritis and Cartilage Open, https://doi.org/10.1016/j.ocarto.2021.100191, 2021. 
  • Black RM, Wang Y, Struglics A, Lorenzo P, Tillgren V, Rydén M, Grodzinsky AJ, Önnerfjord P. "Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model." Osteoarthritis and Cartilage Open, https://doi.org/10.1016/j.ocarto.2020.100099, 2020.
  • Black R, Grodzinsky AJ. "Dexamethasone: chondroprotective corticosteroid or catabolic killer?" Eur Cell Mater, 38:246-263, 2019.
  • Krishnan Y, Grodzinsky AJ. "Cartilage diseases." Matrix Biology, 71-72:51-69, 2018.
  • Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR. "Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis." J Biol Chem, 293(29):11459-11469, 2018.
  • Behrendt P, Feldheim M, Preusse-Prange A, Weitkamp JT, Haake M, Eglin D, Rolauffs B, Fay J, Seekamp A, Grodzinsky AJ, Kurz B. "Chondrogenic potential of IL-10 in mechanically injured cartilage and cellularized collagen ACI grafts." Osteoarthritis and Cartilage, 264-275, 2018.
  • Wang Y, Li Y, Khabut A, Chubinskaya S, Grodzinsky AJ, Önnerfjord P, "Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment." Matrix Biology, 63:11-22, 2017.
  • Grodzinsky AJ, Wang Y, Kakar S, Vrahas MS, Evans CH, "Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis." J Orthop Res, 35:406-411, 2017.

Mechanobiology and Biomechanics of Connective Tissues

  • Connizzo BK, Grodzinsky AJ. "Lose-dose administration of dexamethasone is beneficial in preventing secondary tendon damage in a stress-deprived joint injury explant model." J Orthop Res, 38(1):139-149, 2020.
  • Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ. "Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent." Connect Tissue Res, 61(1):48-62, 2020.
  • Connizzo BK, Grodzinsky AJ. "Release of pro-inflammatory cytokines from muscle and bone causes tenocyte death in a novel rotator cuff in vitro explant culture model." Connect Tissue Res, 6:1-14, 2018.
  • Connizzo BK, Grodzinsky AJ. "Multiscale poroviscoelastic compressive properties of mouse supraspinatus tendons are altered in young and aged mice." J Biomech Eng, 140(5):0501021-8, 2018.
  • Li Y, Frank EH, Wang Y, Chubinskaya S, Huang HK, Grodzinsky AJ, "Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, TNFa and IL-6, but accentuates degradation above a strain threshold." Osteoarthritis and Cartilage, 21:1933-1941, 2013.

Nanomolecular Rheology

  • Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. "Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics." Acta Biomater, 70:249-259, 2018.
  • Connizzo BK, Grodzinsky AJ. "Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology." J Biomech, 54:11-18, 2017.
  • Azadi M, Nia HT, Gauci SJ, Ortiz O, Fosang A, Grodzinsky AJ, "Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse." J Biomechanics, 49:1634-1640, 2016
  • ​Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. "Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds." Sci Rep, 6:37949, 2016.

Drug Delivery for Osteoarthritis

  • Krishnan Y, Rees HA, Rossitto CP, Kim S, Hung HK, Frank EH, Olsen BD, Liu DR, Hammond PT, Grodzinksy AJ. "Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues." Biomaterials, 183:218-233, 2018.
  • Geiger BC, Wang S, Padera Jr. RF, Grodzinsky AJ, Hammond PT. "Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis." Science Translational Medicine, 10(469), 2018.
  • Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM. "Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis." Eur Cell Mater, 34:341-364, 2017.
  • Bajpayee AG, Grodzinsky AJ. "Cartilage-targeted drug delivery: can electrostatic interactions help?" Nature Reviews Rheumatology, 13:183-193, 2017.
  • Bajpayee AG, Quadir MA, Hammond PT, Grodzinsky AJ. "Targeted intra-tissue sustained delivery of dexamethasone using avidin nano-carriers for treating cartilage degeneration." Osteoarthritis and Cartilage, 24:71-81, 2016.

Books

  • Smith DW, Gardiner BS, Zhang L, Grodzinsky AJ, Articular Cartilage Dynamics, Springer, New York, 2018 (in press). 
  • Grodzinsky AJ, Fields, Forces and Flows in Biological Systems, Garland Science (Taylor and Francis), March 8, 2011, textbook, ISBN-13: 9780815342120.
  • Sandell LJ and Grodzinsky AJ, eds., Tissue Engineering in Musculoskeletal Practice, Amer Acad Orthop Surg, Pub., Rosemont, IL., 2004.