Publications

For full list of publications, see PubMed and Google Scholar
 

Mechanobiology and Biomechanics of Connective Tissues

  • Connizzo BK, Grodzinsky AJ. "Release of pro-inflammatory cytokines from muscle and bone causes tenocyte death in a novel rotator cuff in vitro explant culture model." Connect Tissue Res, 6:1-14, 2018.
  • Connizzo BK, Grodzinsky AJ. "Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice." J Biomech Eng, 140(5), 2018.
  • Orozco, GA, Tanska, P, Florea, C, Grodzinsky, AJ, Korhonen, RK, "A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage." Scientific Reports, 8:15599, 2018.
  • Li, Y, Frank, EH, Wang, Y, Chubinskaya, S, Huang, HK, Grodzinsky, AJ, "Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, TNFa and IL-6, but accentuates degradation above a strain threshold." Osteoarthritis and Cartilage, 21:1933-1941, 2013.

Nanomolecular Rheology

  • Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. "Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics." Acta Biomater, 70:249-259, 2018.
  • Connizzo BK, Grodzinsky AJ. "Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology." J Biomech, 54:11-18, 2017.
  • Azadi, M, Nia, HT, Gauci, SJ, Ortiz, O, Fosang, A, Grodzinsky, AJ, "Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse." J Biomechanics, 49:1634-1640, 2016
  • ​Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. "Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds." Sci Rep, 6:37949, 2016.

Drug Delivery for Osteoarthritis

  • Geiger BC, Wang S, Padera Jr. RF, Grodzinsky AJ, Hammond PT. "Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis." Science Translational Medicine, Vol. 10, Issue 469, 2018
  • Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM. "Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis." Eur Cell Mater, 34:341-364, 2017.
  • Bajpayee, AG, Grodzinsky, AJ. "Cartilage-targeted drug delivery: can electrostatic interactions help?" Nature Reviews Rheumatology, 13:183-193, 2017.
  • Bajpayee, AG, Quadir, MA, Hammond, PT, Grodzinsky, AJ. "Targeted intra-tissue sustained delivery of dexamethasone using avidin nano-carriers for treating cartilage degeneration." Osteoarthritis and Cartilage, 24:71-81, 2016.

PTOA: Prevention, Drug Effects, and Repair

  • Krishnan, Y, Grodzinsky, AJ, "Cartilage diseases." Matrix Biology, 71-72:51-69, 2018.
  • Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR. "Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis." J Biol Chem, 293(29):11459-11469, 2018.
  • Behrendt P, Feldheim M, Preusse-Prange A, Weitkamp JT, Haake M, Eglin D, Rolauffs B, Fay J, Seekamp A, Grodzinsky AJ, Kurz B. "Chondrogenic potential of IL-10 in mechanically injured cartilage and cellularized collagen ACI grafts." Osteoarthritis and Cartilage, 264-275, 2018.
  • Wang,Y, Li, Y, Khabut, A, Chubinskaya, S, Grodzinsky, AJ, Önnerfjord, P, "Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment." Matrix Biology, 63:11-22, 2017.
  • Wang,Y, Li, Y, Khabut, A, Chubinskaya, S, Grodzinsky, AJ, Önnerfjord, P, "Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment." Matrix Biology, 63:11-22, 2017.
  • Grodzinsky, AJ, Wang, Y, Kakar, S, Vrahas, MS, Evans, CH, "Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis." J Orthop Res, 35:406-411, 2017.
  • Li, Y, Wang, Y, Chubinskaya, S, Schoeberl, B, Kopesky, P, Grodzinsky, AJ, "Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post traumatic osteoarthritis." Osteoarthritis and Cartilage, 23:266-274, 2015

Books

  • Smith, DW, Gardiner, BS, Zhang L, Grodzinsky, AJ, Articular Cartilage Dynamics, Springer, New York, 2018 (in press). 
  • Grodzinsky, AJ, Fields, Forces and Flows in Biological Systems, Garland Science (Taylor and Francis), March 8, 2011, textbook, ISBN-13: 9780815342120.
  • Sandell, LJ and Grodzinsky, AJ, eds., Tissue Engineering in Musculoskeletal Practice, Amer Acad Orthop Surg, Pub., Rosemont, IL., 2004.